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doi: 10.1038/srep11601

10.1038/s41420-025-02606-6 129 ZhengZ.ShangX.SunK.HouY.ZhangX.XuJ.et al (2024)

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

Depending on the nutrient and its dosage, some side effects may occur very quickly, while others may take a longer time to develop ( For instance, taking a very high dose of one or multiple nutrients may cause gut symptoms that generally develop shortly after taking the supplement ( However, more severe side effects may develop over time as excess amounts of nutrients or unwanted contaminants gradually accumulate in the body

178-180 However, a meta-analysis of eight clinical trials found low-dose naltrexone slightly reduced pain and symptom severity in patients with fibromyalgia but was not significantly more effective than placebo