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The presence of Enterococcus faecalis in PD patients is linked to the metabolism of l-DOPA and dopamine (170)

In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

Various nanoparticles may help provide better targeting and drug delivery of metal complexes for multiple tumor models (Sharma et al., 2018)

Additionally, potential signaling pathways such as SIRT1, PI3K/Akt, and gene expression changes warrant deeper investigation