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It is also worth noting that a large cluster of long heparan polymers on the cell surface could be associated with multiple dimeric c-MET/HGF complexes and in principle induce the higher-order oligomerization of c-METs, and potentially lead to the formation of even larger biomolecular condensates on the cell membrane

Vitetta, L., Zhou, J., Manuel, R., Dal Forno, S., Hall, S., & Rutolo, D

It can range in size from a dime to the width of your body

Complement-dependent cytotoxicity involves the activation and deposition of complement components on the target cell surface, ultimately leading to the formation of the membrane attack complex (MAC)

Published clinical evidence includes a Phase 1b multiple-ascending-dose trial reported by Enebo and colleagues (Lancet, 2021) and a Phase 2 trial in type 2 diabetes reported by Frias and colleagues (Lancet, 2023), both studying cagrilintide together with semaglutide