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Randomization was stratified by HbA1c of less than 85% at screening (yes or no) and country (Japan

Among these, the key ones were the genes encoding albumin (ALB), protein kinase B (AKT) serine/threonine kinase 1 (AKT1), and tumor protein p53 (TP53), and the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway was a critical pathway involved

doi: 10.1172/jci.insight.151544

Both MMF and fumarate are believed to be responsible for the primary therapeutic effects of DMF through activation and inhibition of the transcription factors, Nrf2 ( via the agonism of the hydroxycarboxylic acid receptor 2 ( in vitro and in vivo immunologic actions of DMF ( in vitro causes a rise in the concentration of succinate ( in vivo by using global metabolomics profiling of blood plasma of patients with relapsing-remittent multiple sclerosis treated for 6 weeks with DMF

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