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In silico studies conducted to investigate the potential of hesperidin as a therapeutic agent against SARS-CoV-2 have focused on several biological targets, including major protease (Mpro), spike protein (S protein), RdRp enzymes, human ACE2 receptor, nsp16 2-O-methyltransferase, PLpro, HR1 and RBD, RNA-dependent RNA polymerase (RdRp), TMPRSS2, the receptor-binding domain (RBD) of SARS-CoV-2 and viral proteins such as helicase (Hel), exoribonuclease (ExoN) and guanine-N7 methyltransferase

The liver tissue cells display varying levels of damage

S2, the altered reactions were categorized for two conditions, CBZ_IC50_Biostimulant and CBZ_IC50 representing effect of the presence and absence of biostimulant under CBZ stress respectively

Third, upregulated OXPHOS, inositol phosphate metabolism and glycolysis contribute to activation and pro-inflammatory phenotype of macrophages, respectively