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the gut microbiota, meanwhile, modulates immune homeostasis via the gut-brain axis, with its metabolites (e.g., short-chain fatty acids) enhancing BBB integrity and suppressing neuroinflammation through immunomodulation

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J Infect Dis 185: 405407

(52) Regular users of PPIs have a 44 percent increased risk of dementia compared to those who dont use the drugs

Squalene secreted by tumors can modulate the NF-B pathway through p65, represses CXCL1 transcription, and thereby reduces the recruitment of MDSCs and TAMs into the tumor microenvironment (337)