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A 2019 study published in Obesity the journal of The Obesity Society analyzed nearly 14,000 adults (84% female) and found that patients who used phentermine for longer than 12 months lost significantly more weight at 6 months, one year, and two years compared to those who stopped at three months

This happens when the electrical impulse travels backwards from the ventricles to the atria, initiating another heartbeat while the first heartbeat is still descending into the ventricles