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Because it has been shown that disruption of the nsp9nsp10 cleavage site is not lethal 131 and nsp10 is able to tightly bind to nsp14 or nsp16 (refs 132,133 ), nsp9 may serve as a core regulator in recruiting the nsp10nsp14 or nsp10nsp16 complex for the following capping RTC assembly with N7-methyltransferase activity and 2- O -methyltransferase activity

The three and five positions of the phloside A ring (112) and the C-6 and C-8 positions of the quercetin A ring (113) are the main active centres for scavenging the dicarbonyl compounds MGO and GO