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Food and Drug Administration, Certain bulk drug substances for use in compounding that may present significant safety risks

Historically, it was assumed that vitamin B12 toxicity is virtually impossible

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They are not for human consumption and are not intended to diagnose, treat, cure, or prevent plantar fasciitis, chronic foot pain, sports injuries, soft tissue injury, inflammation, pain, stiffness, reduced mobility, recovery delay, performance decline, or any medical condition.

For patients on newer antidepressants, which are more common (e.g., Prozac, Paxil, Zoloft, Celexa, Effexor), we are unaware of any adverse interactions