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Glutamate, which lowers ammonia through the urea cycle bypass pathway, and phenylacetate/phenylbutyrate (phenylacetate precursor) were originally believed to be the only sources of phenylacetylglutamine (PAGln), one of the main toxins associated with chronic kidney illness (122)

Maccioni L, Gao B, Leclercq S, Pirlot B, Horsmans Y, De Timary P, et al

This is a reasonable hypothesis

Therefore, the main mechanisms and potential implication of therapies under investigation have shifted to the early brain injury, cortical spreading depolarizations, and neuro inflammation