GPX4, once activated, is capable of converting GSH to oxidized GSSG and reducing toxic lipid peroxides (L-OOH) to non-toxic lipid alcohols (L-OH), suggesting that GSH is an essential protective metabolite against ferroptosis (Hwang et al., 2021)
In comparison to healthy control, patients suffering with IBD show a reduced abundance of Firmicutes and a greater prevalence of Enterobacteriaceae (94)
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doi:10.1038/nn1885
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