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doi: 10.1093/carcin/13.5.867 225 WignerP.GrbowskiR.BijakM.Saluk-BijakJ.SzemrajJ

Approved for pediatric GHD (brand discontinued), it's now compounded and used off-label in adults

However, D4 also shows off-target effects blocking other connexin channels, including Cx26, Cx30 and Cx45 522,523

The condition's incidence has accelerated due to increased UV exposure from reduced ozone protection in equatorial regions, higher altitude living, and greater time spent outdoors for work and recreation