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For thiol oxidations to be consequential inside cellsfor example, to inactivate an enzyme population to the extent that a pathway bottleneck arisesthe rate of thiol oxidation must be fast, with a majority of enzyme molecules being oxidized within a cell generation

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Additionally, the overexpression of a MKK6(Glu) mutant, which constitutively activated p38/MAPK, resulted in MT depolymerization and, subsequently, promoted HDF migration and proliferation