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Phase II study of durvalumab (anti-PD-L1) and trametinib (MEKi) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC)

They include non-hormonal therapies like lubricants and vaginally applied nutrient therapies, as well as low- and ultra-low-dose vaginal preparations that supply estrogen directly to the vaginal tissue

The applied HPLC equipment contained a Shimadzu (Kyoto, Japan) model LC-9A HPLC pump with Shimadzu FCV-AL proportioning valve, a Knauer (Bad Homburg, Germany) model A0263 manual injector, a Merck cartridge LiChrosphere 100RP-18 column (250 3.4 mm), a Shimadzu model RF-535 fluorescence monitor (excitation at 365 nm, emission at 430 nm) and Shimadzu Class-VP software (version 4) for pump control, data acquisition and analysis

At The Cosmo Clinic, all drips are prepared and supervised by licensed staff to ensure safety, proper dosage, and sterility, minimizing any risk of side effects or complications

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