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Alterations in DNA methylation and histone acetylation lead to the suppression or activation of genes critical for cognitive function and neuronal health

International Journal for Vitamin and Nutrition Research

10.1371/journal.pone.0011957 20

Several serotonin receptor subtypes have been reported to be overexpressed in colorectal tumors or colorectal cancer cell lines, including 5-HT 1(B, D, F) [152,153], 5-HT 2B [156,157], 5-HT 3C [153], and 5-HT 4 [153]

The interaction of the active site metal ions and the conserved disulfide bond in each subunit is thought to contribute significantly to the stability of the enzyme [32]