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For example, supplementation with Lactobacillus acidophilus KBL409 can alleviate adenine-induced intestinal barrier damage in RF mice, reduce macrophage infiltration, increase regulatory T cells, inhibit the NLRP3 inflammasome, and exert immunomodulatory effects to prevent renal injury [107]

While certain natural products have shown promising results in in vitro models, attributing them with specific therapeutic relevance, especially in in vivo ovarian reserve preservation, remains speculative without clearer mechanistic evidence (Supplementary Appendix 4)