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You have no way to determine how much potency has been lost, which means you cannot calculate an appropriate dose adjustment

Pegloticase may be especially useful in patients with very large collections of uric acid (tophi), especially if these are draining to the skin

One approach involves labeling the proteins with agents that generate a signal when brought into close proximity by the interaction

In brief, the samples were first transferred to a 65 C water bath (GFL) for 5 min, before being transferred to 80 C for 5 min

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