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On the other hand, the p75 NTR receptor has been reported to either induce or prevent apoptosis upon oxidative insult in both in vivo and in vitro models

Knock out of ALCAT-1, an enzyme that promotes cardiolipin peroxidation protected against onset of cellular senescence and preserved mitochondrial function by reducing sensitivity to lipid oxidation

These findings have prompted further studies that look at how the extracellular matrix regulates the functionality of cells, with prior work highlighting the regulatory functions of the mechanical and signaling properties of ECM 59,157,158

Interestingly, iron was found to alter the balance between M1/M2 macrophage polarization, leading to macrophage-driven inflammation and fibrogenesis in nonalcoholic fatty liver disease (NAFLD) [64]

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