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The evolution of intracellular parasitic lifestyle of Mtb could be in part due to the deletion of the cobF gene and the consequent need to uptake vitamin B12 from the host ( One of the major obstacles in controlling TB is the lack of a rapid but efficient diagnostic tool able to differentiate active TB from LTBI

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( D ) Heatmaps showing the relative expression and the fold change in mean expression of proteins forming CI to CIV complexes in the kidneys of Ctrl and cKOt mice

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Consistently, comparing cells expressing HA-ATG2A, which exhibited fewer GFP-LC3B dots and limited localization on GFP-LC3B, cells expressing HA-ATG2A-3CS displayed an increased number of GFP-LC3B dots along with enhanced colocalization between HA-ATG2A-3CS and GFP-LC3B (Fig

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