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(179) demonstrated that in rat models of NASH, HUC-MSCs exosomes enhanced the Nrf2 (Nuclear factor erythroid 2-related factor 2), a protective factor against oxidative stress and 1 [NAD (P) H quinone dehydrogenase 1], a part of cellular adaptive response to stress, which seems to play a significant part in treating NASH (180)

10.1016/j.ibneur.2023.11.002 100 Mar-BausetS.Llopis-GonzlezA.Zazpe-GarcaI.Mar-SanchisA.Morales-Surez-VarelaM

To this end, the development of new therapies, ideally targeting synovitis and inflammatory-related bone erosion in joints, as well as regulating those inflammation-independent factors that can also interfere with bone homeostasis in RA, such as the general RANKL signaling pathway, would be promising for remodeling bone homeostasis in RA

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes

To date, there have been few clinical trials that have examined the effects of supplemental micronutrients on aspects of memory