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As a relatively stable and low-inflammatory precursor phase, AMSU tends to induce heterogeneous nucleation and deposition on damaged articular cartilage surfaces, synovial connective tissue, or cell-derived vesicles at various biological interfaces, and may participate in the uric acid crystallization kinetics process within a certain timescale (3, 1014)

The retina is highly susceptible to oxidative stress as it has a large amount of polyunsaturated fatty acids, it consumes large quantities of oxygen, and it is exposed to visible light

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Ajani JA, Swisher SG