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Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

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Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis

You're more likely to have vitamin B12 deficiency if you have a medical condition where your body can't absorb B12 or you follow a strict vegan diet