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Recently, inactivation of the polycomb repressive complex 2 (PRC2), induced by inactivating mutations in two of its critical constituents SUZ12 and EED , was reported in a large subset of malignant peripheral nerve sheath tumors

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Are there biomarkers such as an increase in serum D-serine or a decrease in urinary N-telopeptide if bone resorption is reduced that can serve as early indicators of efficacy

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