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When the antioxidant system cant withstand iron overload, excessive ROS will attack sensitive fatty acids, trigger peroxidation, destroy the integrity of cell membrane, increase oxidative stress in vivo , and destroy DNA, protein and lipids, thus aggravating lipid metabolism disorder and further causing ferroptosis (40)

Glutathione is the high-quality paint on the outside that determines how bright, even, and radiant the exterior looks

The difference may be due to sexual dimorphism in the expression of Nrf2 ( NRF2 is a transcription factor which induces the transcription of various genes involved in redox balance in response to oxidative stress ( Figure 4B ), while GS and GR levels peaked at the start of the dark period ( Figures 4C, D )

10.1111/ejn.15021 13 AppeldoornC

E., Finlay, M