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200-250 pounds (90-113kg): Consider 450-500mcg daily

The AOD-9604 treatment groups demonstrated measurable improvements across these parameters, suggesting genuine tissue regeneration rather than merely symptomatic relief

Parkinsonism Relat Disord 27:8184 de Lau LML, Koudstaal PJ, Witteman JCM, Hofman A, Breteler MMB (2006) Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease