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The suboptimal dosage of sertraline showed effective pathway targeting by increasing secretion of excess serine and lowering its synthesis (Figure S8B)

This means it cannot be taken directly and must be increased indirectly through other means, within the brain [5]

Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, et al

This aligns with previous findings of increased hydrophobicity in dimeric molecules like monoclonal antibodies compared to their monomeric counterparts ( The increased hydrophobicity of the dimeric RBD signifies a potential for greater aggregation or interaction with hydrophobic surfaces as compared to its monomeric counterpart