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AMPK activation causes cells to utilize their stored fuel more efficiently, improving insulin sensitivity and glucose uptake into muscles

Baumann, H

Br J Clin Pharmacol 2025 demonstrates that co-infusing a GLP-1 agonist with glucagon produces a perfectly additive HR response (+4 bpm + +4 bpm = +7 bpm at 60 min in n=12 lean males), confirming that glucagon drives chronotropy via a parallel pathway independent of GLP-1R cross-reactivity

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Cysteine-rich peptides can provide a source of sulfur-containing amino acids that are also used in the synthesis of glutathione, the antioxidant that protects melanocytes from oxidative stress