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However, in diabetes, oxidative stress and chronic inflammation alter IRP activity, leading to iron metabolism dysregulation, iron overload, and increased ferroptosis ( 2.3 Role of oxidative stress in diabetic cardiomyopathy In DCM, the disruption of iron homeostasis and persistent oxidative stress are key drivers of ferroptosis (62)

-unsaturated aldehydes (alkenals) like acrolein are highly reactive with lysine, cysteine, and histidine through a Michael-type addition as well as with serine, histidine, arginine, threonine, and lysine residues [37, 38]

101, 110 (2016), Application(s): Western blot analysis, mouse SN tissues, Abstract Delivery of Soluble Heme Oxygenase 1 Cell-Penetrating Peptide into Liver Cells in in vitro and ex vivo Models of Cold Ischemia: A.B

[DOI] [PubMed] [Google Scholar] 1212.Qiu GZ, et al

Therapeutic strategies must account for this diversity, either through combination approaches effective against multiple metabolic subtypes or through sequential therapies targeting different populations [77, 78]