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There is evidence that these cytokines do not cross the healthy blood-brain barrier and they are rapidly broken down after release but passage between the CNS and blood still remains a possibility (Steensberg et al., 2006

Phospholipase A2, reactive oxygen species, lipid peroxidation in cerebral ischemia

elegans , included three targeting genes encoding peroxide-detoxifying enzymes: two catalases ( ctl-1 and ctl-2 ) and the mitochondrial 2-Cys peroxiredoxin ( prdx-3 )