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Omaha: University of Nebraska Medical Center

Kelley RK, Verslype C, Cohn AL, Yang TS, Su WC, Burris H, et al

J., Yurkiewicz I

This study successfully identified C5 and SCP2 as promising drug targets through Mendelian randomization and Bayesian colocalization, and highlighted beta-Amyrone as a potential dual-target inhibitor with strong binding affinity to both proteins, paving the way for innovative treatment strategies