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Cell 148: 421433 [DOI] [PMC free article] [PubMed] [Google Scholar] 57

Multiple signaling pathways that initiate inflammatory responses as a result of mitochondrial dysfunction have been discovered, particularly cyclic GMP-AMP synthase (cGAS) - Stimulator of Interferon Genes 1 (STING1) and inflammasome signaling pathways (see Figure 4 ) (158)