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Enteric-coated aspirin induces small intestinal injury via the nrf2/gpx4 pathway: A promising model for chronic enteropathy

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10.1038/onc.2012.529 33 DeraA

Key Features: Provides essential Vitamin B12 supplementation for animals

Graphical Abstract Similar content being viewed by others Abbreviations 4-HNE: 4-Hydroxynonenal ac4C: N 4 -acetylcytidine AIFM2: Apoptosis-inducing factor mitochondria-associated 2 (synonym for FSP1) BRCA: Breast cancer gene ESCRT-III: Endosomal sorting complex required for transport III CHMP5/6: Charged multivesicular body protein 5/6 (ESCRT-III subunits) CoQ10: Coenzyme Q10 (ubiquinone-10) CoQH2: Ubiquinol (reduced form of CoQ10) DAMPs: Damage-associated molecular patterns DHODH: Dihydroorotate dehydrogenase FEZF1-AS1: FEZ family zinc finger 1 antisense RNA 1 FSP1: Ferroptosis suppressor protein 1 GAPLINC: Gastric adenocarcinoma predictive long intergenic noncoding RNA GPX4: Glutathione peroxidase 4 GSH: Glutathione HCC: Hepatocellular carcinoma HIF-1: Hypoxia-inducible factor 1 IHC: Immunohistochemistry ICD: Immunogenic cell death FSEN1: Ferroptosis sensitizer 1 iFSP1/icFSP1: Inhibitor of FSP1/inducer of condensation of FSP1 (specific inhibitor names) KRAS: Kirsten rat sarcoma viral oncogene homolog KEAP1: Kelch-like ECH-associated protein 1 LINK-A: Long intergenic noncoding RNA for kinase activation LLPS: Liquidliquid phase separation lncRNA: Long noncoding RNA MDA: Malondialdehyde METTL3: Methyltransferase 3 m 6 A: N 6 -methyladenosine miRNA/miR: MicroRNA MAPK: Mitogen-activated protein kinase NAT10: N -acetyltransferase 10 NAD(P)H: Nicotinamide adenine dinucleotide (phosphate) NMT: N -myristoyltransferase NRF2: Nuclear factor erythroid 2related factor 2 OGD/R: Oxygenglucose deprivation/reoxygenation PD-1/PD-L1: Programmed cell death protein 1/programmed death-ligand 1 SP1: Specificity protein 1 (transcription factor) TAMs: Tumor-associated macrophages TNBC: Triple-negative breast cancer TME: Tumor microenvironment TRIM21: Tripartite motif-containing protein 21 (E3 ubiquitin ligase) VKH2: Vitamin K hydroquinone Acknowledgements The graphical abstract and all schematic figures in this manuscript were created with BioRender.com