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The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains

2,3-Dihydroxybenzoic acid was shown to chelate both copper and iron in various chelation models, such as the ferrozine assay (Harcrov et al., 2025)

However, for musculoskeletal and systemic applications, subcutaneous injection delivers the peptide directly into systemic circulation at predictable concentrations

Insulin-sensitive lean subjects (MHL) were identified by a Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), with scores below 1.2, while insulin-resistant obese subjects (MUO) were identified by a HOMA-IR, with scores equal or greater than 2.5 (details are shown in Table 3)