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*Correspondence: Haider Raza, [email protected] This article was submitted to Metabolic Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This results in exacerbated oxidative stress, as demonstrated by elevated malondialdehyde and 8-isoprostane levels in HF patients, along with reduced myocardial antioxidant enzyme activity (Mallat et al., 1998)