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One report describes temporary neurological symptoms in two newborns whose mothers drank more than 2L per day of an herbal tea mixture that contained fennel.54 The toxicity was due to an essential oil called anethole, a phytoestrogen that occurs naturally in fennel and can be excreted in breast milk

While lifestyle modifications can reduce serum UA levels, dietary changes alone may not adequately optimize serum UA levels, necessitating specific treatments

The active form of calcitriol exerts its anti-inflammatory activity by suppressing pro-inflammatory cytokines and HBDs and slowing down the chemical responses of dendritic cells, which are abundant in psoriatic lesions [131, 132]

In vivo studies with this PROTAC have not been presented 108

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