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D., Cui, P

doi:10.1152/ajpendo.00201.2006 Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ

The reason: prolonged continuous exposure downregulates IGF-1 receptor density (receptor desensitization)

Because IGF-1 is a central mediator of GHs effects, even minor deviations can disproportionately alter metabolism, growth, and repair processes

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