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General Procedure C for Coupling the modified Amine 3a to 3i to GDP 6a to 6i The amine ( 3a 3 i , 2.5 mmol, 5 equiv.) was dissolved in dry DMF (5 mL, c = 0.5 M), and slowly added to a solution of GDP 5 ( c = 25 mM in DMFCH 3 OH (134:1), 1 equiv.) and N, N-Diisopropylethylamine (DIPEA, C 8 H 19 N, 129.25 g/mol, 0,76 g/mL, 2.5 mmol, 5 equiv)

To achieve optimal skin lightening effects, we recommend undergoing two to three treatments per week for a period of at least three months

Single KOs were maintained through heterozygous breeding, while double KOs were bred homozygously and WT mice were age-matched controls

doi: 10.4254/wjh.v7.i10.1325 38