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Bellut et al., 2021)

UGTs are integral membrane proteins of the endoplasmic reticulum, with the active site facing the ER lumen (latency concept: full activity requires membrane disruption or detergent in vitro)

31,34 As a consequence, there is a growing interest in neuroprotective interventions that are both safe and improve long-term neurodevelopmental outcomes for preterm neonates