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However, the in vitro co-culture assay did not detect a reduction in the number of neural progenitors (Fig

However, on the TNF flow cell surface, all dosed subjects in cohort 7 showed increasing signal compared to baseline which was confirmed with the anti-human IgG reagent, but not the AMG 966-specific antibody 1A3, indicating these subjects developed endogenous anti-TNF antibodies as a result of AMG 966 treatment ( Figures 8F, H )

Youssef, M

Several autistic models showed an increase in neuronal apoptosis resulting from the decrease in the expression of Bcl-2/Bcl-2-associated X protein (Bax) that increases activation of caspase-3, boosting uncontrolled apoptosis and eventually resulting in ASD

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