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Description

Cysteine is a rate-limiting precursor substrate for GSH synthesis, and its level is regulated by SLC7A11 encoding the cystine/glutamate transporter XCT, which is primarily responsible for the export of glutamine in exchange for extracellular cystine [9]

The mutant nanobodies were then selectively coupled by a stable oxime bond to bifunctional linkers, with an alkoxy-amine on one terminus and an azide or cyclooctyne group on the other (Fig