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This non-invasive brain stimulation paradigm deserves further investigation in larger randomized trials and with various neurophysiologic assessments, especially that the mechanism of tACS, in association with the glutamatergic pathway, has been understudied

To examine the essential functionality of CHCHD2 in the context of GBM, the U87vIII CHCHD2 KO cells were derived using CRISPR-Cas9 following previously published protocols (28,29) (Fig