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Although these findings did not reach statistical significance, they provide additional evidence for the antidiabetic effect of the 4-week intermittent fasting from dawn to sunset

aurantiifolia was deemed safe in mice at doses below 3,000 mg/kg, but doses exceeding 3,500 mg/kg were found to be toxic to rats (244, 246)

doi: 10.1016/j.bbabio.2008.11.003 48 Fisher-WellmanK

In the body, oxygen often forms a harmful free-radical state that can destroy healthy tissue and serve as a source for aging and many disease processes

69 Therefore, these NAD + -dependent enzymes, namely, sirtuins, PARPs, and cADPRSs, are able to coregulate each other in competition for the same intracellular limiting NAD + pool