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Nutr Metab (Lond) 2012;9:98

At the same time, the authors of these publications pointed out that the full RXR agonist may have numerous side effects

During somatic cell reprogramming, vitamin C-mediated removal of histone modifications such as H3K4me3 and H3K36me3, potentially by KDM5 and KDM2, respectively, can turn off the expression of genes, while demethylation of H3K9me2/me3 by members of the KDM3/4/7 family can remodel heterochromatin regions that can facilitate DNA hypomethylation at these otherwise silenced loci (Li et al., 2009

doi: 10.3390/nu12082395 Adaikalakoteswari et al Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes Clin Epigenetics

Therefore, while SmTGRs interaction with Trx reduces the overall net reoxidation rate of TGR this cannot be assigned to a specific observed process