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Retrieved 11 January 2023

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Moreover, -syn overexpression in iPSCs compared with controls reduced the enzymatic activity of multiple lysosomal enzymes, including GCase, which is essential for the proper functioning of the autophagolysosome (Mazzulli et al., 2011, 2016)

Here, we focused primarily on the acute mitochondrial impact of 5FU, and although we arrived at the combination of 5FU and mitochondrial inhibitors (more specifically, 5FU and metformin) somewhat serendipitously, we have now generated evidence to support the use of 5FU and metformin combinations not only in patients with resistant or relapsed disease as previously suggested by others, but also in treatment-naive, first-line chemotherapy settings

Glutamine provides direct fuel for the cells of the intestinal lining, while glutathione helps reduce oxidative stress and inflammation within the gut environment