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It removes the doubt, which is essential for good science

Finally, as expected a combination of four Pfcrt 76 and Pfmdr1 86 haplotypes namely K76-N86, K76-86Y, 76T-N86, 76T-86Y in comparison to CQ median IC50 value show that, K76T is the most important allele in CQ drug response (Table 3)

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Benzene exposure induces gut microbiota dysbiosis and metabolic disorder in mice

Its weighing whether the substance can be consistently characterized, whether there are safety concerns (including impurities and immunogenicity), and whether the proposed uses have any credible evidence behind them