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Mysteries of metals in metalloenzymes

A.ZargarB.HamidR.ZargarO.DarP

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Our results indicate that absence of GliT may lead to accumulation of intracellular gliotoxin which is reduced, non-enzymatically, by GSH, analogous to the situation in animal cells as demonstrated by Bernardo et al

Glutathione has also emerged a key modulator of xenobiotic toxicity, most notably the persistent organic pollutants which are associated with many diseases of impaired metabolic activity, including diabetes, obesity, and cardiovascular disease