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Overproduction of ROS is involved in the pathogenesis of acne vulgaris via various pathways, including activation of mTOR, peroxisome proliferator-activated receptors (PPARs), and toll-like receptors (TLRs) (176178)

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10.1097/CEJ.0000000000000387 21 BurdE

For example, TRPV1, an ionchannel involved in heat nociception and present on the innervated nerves has been shown to be responsible for NGFreceptor (trkA)mediated remodeling in DRG neurons ex vivo

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