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Determine which kind of B12 is most absorbable based off of COMT and VDR SNP status Support the Long Route pathway utilizing folate or 5-methyl-THF (5-MTHF), for MTHFR mutations Customized support Rich's protocol While Yasko pioneered the methylation protocol for autism, Rich Van Konynenburg, trained as a physicist, was the first to apply the methylation protocol to CFS/ME and fibromyalgia

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Chronic activation of these glial cells drives neuroinflammatory processes that accelerate neurodegeneration, making their modulation a critical therapeutic target

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Its primary actions include: Increasing slow-wave (delta) sleep the deepest, most physically restorative sleep stage Modulating corticotropin-releasing hormone (CRH) reducing the HPA axis signalling that keeps cortisol elevated Influencing LH and somatostatin release both relevant to testosterone and growth hormone secretion Antioxidant activity preclinical data suggests DSIP has direct free-radical scavenging properties (3) Thermoregulatory effects potentially lowering basal body temperature in a manner consistent with natural sleep onset The net effect is not sedation