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In addition, -KG is exported from mitochondria through SLC25A11 to the cytosol 21 and then participates in fatty acid biosynthesis and NADH generation 22 (Fig

For instance, genes like KCNK3 and GAS5 demonstrate dual functionality in both blood pressure regulation and tumor suppression, highlighting epigenetic plasticity as a mediator of comorbid disease risk [69, 70, 274,275,276]