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1 Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age, characterized by a heterogeneous clinical presentation involving hormonal, reproductive, and metabolic dysregulation (1)

& Azizi, H

Interestingly, arsenic can promote calpain activation in cell-free systems, indicating that calpain proteases could be a direct target for arsenic-induced metabolic and immune alterations (195)